The Medicine Machine
Modern Technology & Mother Nature For thousands of years, nature has been the best medicine cabinet around. Natural products are drugs derived from nature, typically plants or microbes, and have...
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Interrupting HIV
Therapies In HIV Pipeline Medicine has made gigantic strides in understanding and treating the human immunodeficiency virus (HIV) since its emergence in the early 1980s. Thanks to robust drug discovery...
View ArticleDrugging The Undruggable
Antagonists Fight A Good Fight Small molecule inhibitors, also known as antagonists in the industry, fight a good fight. In fact, many drugs on the market today work by inhibiting overactive,...
View ArticleAttacking All Angles Of Alzheimer’s
Alzheimer’s Pipeline Roundup Alzheimer’s disease ranks as one of the toughest nuts to crack within drug discovery and development. Current treatments merely manage symptoms, so finding a better...
View ArticleUnmasking Multiple Sclerosis
Many Channels Available To Impede MS Progression Continuing our series on central nervous system (CNS) disorders—previously covering Alzheimer’s and Huntington’s—we pivot to unmask Multiple Sclerosis...
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Two Monoclonal Antibodies Walk Into The Market
Attacking Asthma & Pushing Out Psoriasis Two new monoclonal antibodies debuted on the market thanks to FDA approvals last month. Both treat chronic inflammatory conditions: Lilly’s (Indianapolis,...
View ArticleAn Inborn Error Of Metabolism
Diet Soda’s Ominous Warning “Phenylketonurics—contains phenylalanine” is listed on many diet sodas, including Diet Coke and Diet Pepsi. There is no elaboration, just an ominous warning in bold...
View ArticleDisrupting The Cycle
Circadian Rhythms Govern More Than 24 Hours Of Your Day Overnight shift workers, students pulling an all-nighter to cram for a final exam, and business people rushing between time zones all share one...
View ArticleAttack Of The Migraine
New Avenues For Migraine Therapy Migraines. One of the most convenient excuses to get out of work or dinner with your mother-in-law. More than just a headache, migraines often include symptoms like...
View ArticlePushing the Self-Destruct Button
Pushing the Self-Destruct Button Breakthrough drug Venclexta charged onto the marketplace three months early to battle chronic lymphocytic leukemia. AbbVie’s (North Chicago, IL) and Roche’s (Basel,...
View ArticleOn A Tumor’s Turf
TACKLING THE SPACE AROUND SOLID TUMORS Covering the science behind T-cell-based immunotherapies has been the name of the game for our past couple of issues. CAR-T and TCR therapies show significant...
View ArticleWithout A Treg To Stand On
Regulatory T-Cells Make A Pathway After our focus on T-cell activated immunotherapies revving up the immune response, we turn to the other side of the coin—a subset of helper T-cells known as...
View ArticleBreaking Bad With NSCLC & SCLC
BREAKING BAD The hit TV series Breaking Bad features anti-hero Walter White, who starts out as a sympathetic character: a mild-mannered high school chemistry teacher with a nagging cough that turns out...
View ArticleThe Antibiotic Economy
THE STATE OF ANTIBACTERIALS One of the greatest public health challenges of the 21st century is antibiotic resistance, which occurs when a few bacteria in a given population develop a genetic mutation...
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Killing Cancer At Its Stem Cell Origin
Killing Cancer When it comes to killing cancer, eradicating every single cell is the goal. But did you know there are different kinds of cancer cells? One specific type, called cancer stem cells (CSC),...
View ArticleThe Science Behind The Opioid Epidemic
A Big Pain The opioid addiction crisis gained attention at the highest levels of U.S. policy circles this past year. Presidential candidates that disagreed on nearly everything else vowed to make...
View ArticleUnwiring The Biology Of Fibrosis
Fibrotic Disease Innovations Fibrotic diseases — organ and tissue disorders that occur as a result of the buildup of excessive scar tissue — are sounding the alarm in the biotech sector. A silent...
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Eye Of The Cytokine Storm
Understanding CAR-T Safety Chimeric antigen receptor therapy (CAR-T) is our top technology pick of 2016, blazing trails in drug development with its innovative approach of using engineered immune cells...
View ArticleSwallowing A Biologic Drug?
Surviving The Stomach Is Key Over the past two decades, biologic drugs — drugs composed of proteins produced by living cells — have become the safest, most effective top sellers within the...
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Taking A Swing At Allergies
HOW DO ALLERGIES DEVELOP? Watching a game at the ballpark and digging into a bag of peanuts is a source of entertainment for many Americans. For the 15 million who suffer from peanut allergies, the...
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